Advanced Quantitative Flow and Wall Shear Stress Analysis at 3T: 2D Vs 3D Time-Resolved MR Velocity Mapping
نویسندگان
چکیده
Introduction: Time-resolved (CINE) phase contrast (PC) MRI permits the assessment of blood flow within entire 3D vascular structures [1, 2]. The resulting high-dimensional datasets (3 spatial dimensions, 3 velocity directions, and time) require new visualization and quantification methods to derive reliable clinical parameters. In this context, an advanced flow quantification tool was developed based on detailed planar analysis of measured three-directional velocity fields [2]. State of the art interpolation and numerical methods were employed to provide optimal quantitative assessment of flow and derived vessel wall parameters such as wall shear stress (WSS). The aim of this study was to evaluate the accuracy of in vivo blood flow and vessel wall parameters determined from transversal planes retrospectively defined on 3D CINE PC data with 3-directional velocity encoding (3D-CINE-3dir.PC) by comparison after registration to conventional 2D CINE PC data with 3-directional velocity encoding (2D-CINE-3dir.PC). Specifically, the influence of spatial and temporal resolution, in several planes along the thoracic aorta was investigated in a volunteer study.
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Methodology for Optimal Quantitative Flow Analysis by planar analysis of CINE Phase Contrast 2D or 3D MR data
Introduction: Time-resolved (CINE) phase contrast (PC) MRI allows measurement of time resolved threedirectional velocities within entire 3D vascular structures [1, 2]. The information contained in the PC data is not limited to volumetric flow, but also includes derived quantities such as wall shear stress (WSS), the viscous drag of blood on the arterial wall, which is believed to play a key rol...
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